Studies with Antigens

Studies of antigens associated with Hodgkin's disease.

Studies on Artificial Antigens

The genetic transmission of the capacity to develop an immune response to hapten-polylysine conjugates was studied in guinea pigs. 82 per cent of the 22 offspring of 8 pairs of responder (guinea pigs which are capable of an immune response) parents were also responders, whereas, none of the 26 offspring of 9 pairs of non-responder parents were responders. None of 11 strain 13 guinea pigs and 10...

Studies of colonic carcinoma antigens.

Extracts of human colonic adenocarcinomata were made with perchloric acid and shown to contain antigens which were not present in pooled samples of normal colonic mucosa or in healthy colonic mucosa from patients providing the tumours. Antisera prepared against the tumour extracts gave two precipitin lines on immunodiffusion, and antiserum prepared in Montreal according to the methods devised b...

Lymphocyte antigens in systemic lupus erythematosus: studies with heterologous antisera.

Rabbit antisera were produced against pooled living lymphocytes from 25 patients with active systemic lupus erythematosus (SLE). Lymphocytes collected at plasmapheresis or venipuncture were frozen in liquid nitrogen and later coated with rabbit antibody to normal human tonsils and normal thymocytes immediately before intravenous immunization of rabbits. Antisera were subsequently extensively ab...

Serological Studies on Azoproteins Antigens Containing Azocomponents with Aliphatic Side

The first studies in this series included only simple aromatic amino compounds. An extension of the investigation to aliphatic substances, such as tartaric acid (1), pepfides (2) and carbohydrates (3, 4), was made possible by the expedient of combining them to aromatic amines to form diazotizable compounds which could be linked to protein. Since simple aliphatic compounds have not been examined...